Siwin-IO31
Iodotrimethylsilane
Typical properties
Product No. | Siwin-IO31 |
Chemical Name | Iodotrimethylsilane |
CAS NO. | 16029-98-4 |
Formula | (CH3)3SiI |
Appearance | Colorless or light red flammable liquid |
Density (ρ20℃，g/m³) | 1.406 |
Flash point (℃) | -31 |
Boiling point (℃) | 106 |
Purity (by GC, %) | 98min |
Chemical Structure |
|
Application
Pharmaceutical Industry
Antibiotic Synthesis
A critical intermediate widely used in synthesizing cephalosporin antibiotics (e.g., ceftazidime, cefprozil), accounting for over 96% of its applications.
Plays a key role in synthesizing antiviral, anticancer, and other drugs.
Deprotection of Protective Groups
Efficiently removes protective groups like N-Boc and N-Cbz, simplifying synthesis steps.
Organic Synthesis
Functional Group Protection and Transformation
Acts as a silylating agent to protect hydroxyl, carboxyl, amino, and other functional groups, enhancing reaction selectivity.
Converts alcohol hydroxyl groups to trimethylsilyl ethers or carbonyl groups to enol silyl ethers46.
C-O Bond Cleavage
Efficiently cleaves C-O bonds in ethers, esters, carbonates, ketals, and lactones under neutral conditions, with cleavage priority: tertiary alkyl > benzyl > allyl > secondary alkyl > primary alkyl.
Fine Chemicals and Pesticides
Used to synthesize organosilicon derivatives (e.g., silylimidate esters, alkyl/alkenyl silanes)5.
Serves as an intermediate in synthesizing active pesticide ingredients.
Carbohydrate Chemistry and Materials Science
Selectively converts acetal hydroxyl groups to iodides in carbohydrate chemistry while preserving other functional groups.
Participates in preparing high-temperature-resistant and aging-resistant polymer materials
Package & Storage
235kg/drum
Store tightly at room temperature in dry shadow place, avoid contact with alkali and acid , away from fire source.
